Quasicontinuous Exhaust Scenario for a Fusion Reactor: The Renaissance of Small Edge Localized Modes.

Tokamak operational regimes with small edge localized modes (ELMs) could be a solution to the problem of large transient heat loads in fusion reactors. A ballooning mode near the last closed flux surface governed by the pressure gradient and the magnetic shear there has been proposed for small ELMs. In this Letter, we experimentally investigate several stabilizing effects near the last closed flux surface and present linear ideal simulations that indeed develop ballooninglike fluctuations there and connect them with nonlinear resistive simulations. The dimensionless parameters of the small ELM regime in the region of interest are very similar to those in a reactor, making this regime the ideal exhaust scenario for a future device.

Simulating the nonlinear interaction of relativistic electrons and tokamak plasma instabilities: Implementation and validation of a fluid model.

For the simulation of disruptions in tokamak fusion plasmas, a fluid model describing the evolution of relativistic runaway electrons and their interaction with the background plasma is presented. The overall aim of the model is to self-consistently describe the nonlinear coupled evolution of runaway electrons (REs) and plasma instabilities during disruptions. In this model, the runaway electrons are considered as a separate fluid species in which the initial seed is generated through the Dreicer source, which eventually grows by the avalanche mechanism (further relevant source mechanisms can easily be added). Advection of the runaway electrons is considered primarily along field lines, but also taking into account the E×B drift. The model is implemented in the nonlinear magnetohydrodynamic (MHD) code jorek based on Bezier finite elements, with current coupling to the thermal plasma. Benchmarking of the code with the one-dimensional runaway electron code go is done using an artificial thermal quench on a circular plasma. As a first demonstration, the code is applied to the problem of an axisymmetric cold vertical displacement event in an ITER plasma, revealing significantly different dynamics between cases computed with and without runaway electrons. Though it is not yet feasible to achieve fully realistic runaway electron velocities close to the speed of light in complete simulations of slowly evolving plasma instabilities, the code is demonstrated to be suitable to study various kinds of MHD-RE interactions in MHD-active and disruption relevant plasmas.

Beam-Ion Acceleration during Edge Localized Modes in the ASDEX Upgrade Tokamak.

The acceleration of beam ions during edge localized modes (ELMs) in a tokamak is observed for the first time through direct measurements of fast-ion losses in low collisionality plasmas. The accelerated beam-ion population exhibits well-localized velocity-space structures which are revealed by means of tomographic inversion of the measurement, showing energy gains of the order of tens of keV. This suggests that the ion acceleration results from a resonant interaction between the beam ions and parallel electric fields arising during the ELM. Orbit simulations are carried out to identify the mode-particle resonances responsible for the energy gain in the particle phase space. The observation motivates the incorporation of a kinetic description of fast particles in ELM models and may contribute to a better understanding of the mechanisms responsible for particle acceleration, ubiquitous in astrophysical and space plasmas.

Resistive reduced MHD modeling of multi-edge-localized-mode cycles in Tokamak X-point plasmas.

The full dynamics of a multi-edge-localized-mode (ELM) cycle is modeled for the first time in realistic tokamak X-point geometry with the nonlinear reduced MHD code jorek. The diamagnetic rotation is found to be instrumental to stabilize the plasma after an ELM crash and to model the cyclic reconstruction and collapse of the plasma pressure profile. ELM relaxations are cyclically initiated each time the pedestal gradient crosses a triggering threshold. Diamagnetic drifts are also found to yield a near-symmetric ELM power deposition on the inner and outer divertor target plates, consistent with experimental measurements.

Mechanism of edge localized mode mitigation by resonant magnetic perturbations.

A possible mechanism of edge localized modes (ELMs) mitigation by resonant magnetic perturbations (RMPs) is proposed based on the results of nonlinear resistive magnetohydrodynamic modeling using the jorek code, realistic JET-like plasma parameters and an RMP spectrum of JET error-field correction coils (EFCC) with a main toroidal number n=2 were used in the simulations. Without RMPs, a large ELM relaxation is obtained mainly due to the most unstable medium-n ballooning mode. The externally imposed RMP drives nonlinearly the modes coupled to n=2 RMP which produce small multimode relaxations, mitigated ELMs. The modes driven by RMPs exhibit a tearinglike structure and produce additional islands. Mitigated ELMs deposit energy into the divertor mainly in the structures ("footprints") created by n=2 RMPs, however, slightly modulated by other nonlinearly driven even harmonics. The divertor power flux during a ELM phase mitigated by RMPs is reduced almost by a factor of 10. The mechanism of ELM mitigation by RMPs proposed here reproduces generic features of high collisionality RMP experiments, where large ELMs are replaced by small, much more frequent ELMs or magnetic turbulence. Total ELM suppression was also demonstrated in modeling at higher RMP amplitude.

Early detection of neutralizing antibodies to interferon-beta in multiple sclerosis patients: binding antibodies predict neutralizing antibody development.

BACKGROUND: Neutralizing antibodies (NAb) affect efficacy of interferon-beta (IFN-b) treatment in multiple sclerosis (MS) patients. NAbs evolve in up to 44% of treated patients, usually between 6-18 months on therapy. OBJECTIVES: To investigate whether early binding antibody (BAb) titers or different IFN-b biomarkers predict NAb evolution. METHODS: We included patients with MS or clinically isolated syndrome (CIS) receiving de novo IFN-b treatment in this prospective European multicenter study. Blood samples were collected at baseline, before and after the first IFN-b administration, and again after 3, 12 and 24 months on that therapy; for determination of NAbs, BAbs, gene expression of MxA and protein concentrations of MMP-9, TIMP-1, sTRAIL, CXCL-10 and CCL-2. RESULTS: We found that 22 of 164 (13.4%) patients developed NAbs during a median time of 23.8 months on IFN-b treatment. Of these patients, 78.9% were BAb-positive after 3 months. BAb titers ≥ 1:2400 predicted NAb evolution with a sensitivity of 74.7% and a specificity of 98.5%. Cross-sectionally, MxA levels were significantly diminished in the BAb/NAb-positive samples; similarly, CXCL-10 and sTRAIL concentrations in BAb/NAb-positive and BAb-positive/NAb-negative samples, respectively, were also diminished compared to BAb/NAb-negative samples. CONCLUSIONS: BAb titers reliably predict NAbs. CXCL-10 is a promising sensitive biomarker for IFN-b response and its abrogation by anti-IFN-b antibodies.

High-dose intravenous interferon-beta in multiple sclerosis patients with high-titer neutralizing antibodies (HINABS II) - A pilot study.

BACKGROUND: Neutralizing antibodies (NAb) against interferon-beta (IFNß) affect its treatment efficacy. So far, there are no anti-NAb strategies available. OBJECTIVES: To investigate if the repeated administration of high-dose IFNß-1b intravenous in NAb positive multiple sclerosis (MS) patients induces tolerance and establishes IFNß bioavailability as measured by the induction of myxovirus protein A (MxA). METHODS: Nine MS patients with NAb titers >500 10-fold reduction units (TRU) received 1500µg IFNß-1b intravenously once weekly over three months. Blood samples were collected at screening, monthly during the treatment period (before and four hours after IFNß administration), and at follow-up after 6 months for determination of NAbs and MxA expression. RESULTS: Median NAb titer at baseline was 1429TRU. NAb titers determined before each infusion did not significantly change over the treatment period and were not different at follow-up compared to baseline. However, NAb titers were significantly decreased four hours after IFNß infusions (by roughly 50%) and MxA mRNA levels were significantly elevated reaching a median value of 206. CONCLUSIONS: Weekly intravenous administration of IFNß in patients with high NAb titers established its bioavailability, but failed to induce tolerance towards IFNß.

[Lymphadenopathy and constitutional symptoms. Progress of a low-grade follicular lymphoma?]. / Generalisierte Lymphadenopathie und B-Symptomatik. Progression eines indolenten Non-Hodgkin-Lymphoms?

Atypical presentation of Churg-Strauss syndrome includes lymph-node and parenchymatous organ involvement which mimics the clinical presentation of lymphoproliferative disorders.A 54-year old man with a history of a low-grade follicular lymphoma presented with rapidly growing abdominal lymph-nodes and hepatic, renal and pulmonary infiltrations. CT guided biopsies to verify either lymphoma or infections showed eosinophilic, necrotizing, granulomatous vasculitis leading to the diagnosis of atypical Churg-Strauss syndrome. Within a few days of cyclophosphamide and prednisone treatment the clinical presentation improved and imaging studies detected regression of all manifestations during follow-up.